Weight | 365.842 g/mol |
---|---|
Formula | C16H16ClN3O3S |
Hydrogen Acceptors | 4 |
Hydrogen Donors | 2 |
Aromatic Rings | 2 |
Rotatable Bonds | 2 |
metolazone
Zaroxolyn · Mykrox · Diulo
56436-31-8, 56436-32-9, 17560-51-9
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- Sigma-Aldrich - metolazone119.00 - 456.00 USD
- Fisher Scientific - Search for metolazone
- TCI - Search for metolazone
- Metolazone in treatment of severe refractory congestive cardiac failure (The Lancet, 1990)
- Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature. (Cardiovascular Drugs and Therapy, 2005)
- Proximal tubular actions of metolazone and chlorothiazide (American Journal of Physiology, 1973)
- Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough (The Journal of Clinical Pharmacology, 1997)
- Thiazide diuretic drug receptors in rat kidney: identification with [3H]metolazone (Proceedings of the National Academy of Sciences of the United States of America, 1988)
- Effects of metolazone in man: Comparison with chlorothiazide (Kidney International, 1972)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Zaroxolyn
- Mykrox
- Diulo
- Microx
- SR72022
- UCB Pharma Brand of Metolazone
- SR-720-22
- SR 720 22
- Celltech Pharmaceuticals Brand of Metolzone
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SMILESCC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
-
InChIKeyAQCHWTWZEMGIFD-UHFFFAOYSA-N
- Pubchem - metolazone
- Wikipedia - metolazone
Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases.
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Synthesis
23380-54-3
+
Reactant
(Alkylation of primary amines)
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