| Weight | 390.52 g/mol |
|---|---|
| Formula | C23H34O5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 6 |
Mevastatin (73573-88-3)
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#695 in Neuroscience
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#1252 in Biochemistry
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#3095 in Biology
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#3868 in Chemistry
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- Sigma-Aldrich - Mevastatin109.50 USD
- Fisher Scientific - Search for Mevastatin
- TCI - Mevastatin130.00 - 440.00 USD
- Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice (Stroke, 2001)
- Relative Lipophilicities, Solubilities, and StructurePharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin (Journal of Pharmaceutical Sciences, 1991)
- HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2 (Carcinogenesis, 2001)
- Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. (Journal of Molecular Biology, 2005)
- Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis. (Fertility and Sterility, 2004)
- The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells (BMC Cancer, 2008)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
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InChIKeyAJLFOPYRIVGYMJ-UHFFFAOYSA-N
- Pubchem - Mevastatin
- Wikipedia - mevastatin
Mevastatin (compactin, ML-236B) is a hypolipidemic agent that belongs to the statins class. It was isolated from the mold Penicillium citrinum by Akira Endo in the 1970s, and he identified it as a HMG-CoA reductase inhibitor, i.e., a statin. Mevastatin might be considered the first statin drug; clinical trials on mevastatin were performed in the late 1970s in Japan, but it was never marketed.
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