| Weight | 320.046 g/mol |
|---|---|
| Formula | C14H10Cl4 |
| Hydrogen Acceptors | 0 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
mitotane (53-19-0)
Lysodren · Khloditan · o,p-DDD
Score:
#820 in Biology
,
#907 in Chemistry
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- Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. (The New England Journal of Medicine, 1990)
- Adjuvant mitotane treatment for adrenocortical carcinoma. (The New England Journal of Medicine, 2007)
- Adrenal cortical carcinoma : epidemiology and treatment with mitotane and a review of the literature (Cancer, 1993)
- Optimal treatment of adrenocortical carcinoma with mitotane: results in a consecutive series of 96 patients (British Journal of Cancer, 1994)
- Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial (Endocrine-related Cancer, 2005)
- Mitotane Use in Inoperable Adrenal Cortical Carcinoma (JAMA, 1973)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Lysodren
- Khloditan
- o,p-DDD
- Chlodithane
- ortho,para DDD
- ortho,para-DDD
- Chloditan
- Mytotan
-
SMILESC1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
-
InChIKeyJWBOIMRXGHLCPP-UHFFFAOYSA-N
- Pubchem - mitotane
- Wikipedia - mitotane
Mitotane, sold under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome. It is a derivative of p,p'-DDT and an isomer of p,p'-DDD, and is also known as 1,1-(dichlorodiphenyl)-2,2-dichloroethane (o,p'-DDD).
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Synthesis
CHLOROBENZENE
+
Reactant
(Friedel-Crafts alkylation)
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mitotane
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