| Weight | 392.499 g/mol |
|---|---|
| Formula | C24H28N2O3 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 7 |
naftopidil (57149-07-2)
1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
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- Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. (Japanese Journal of Pharmacology, 1999)
- Comparison of two 1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study (BJUI, 2006)
- Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and -1D adrenergic receptor antagonists, on bladder activity in rats. (Neuroscience Letters, 2002)
- Comparison of tamsulosin and naftopidil for efficacy and safety in the treatment of benign prostatic hyperplasia : a randomized controlled trial (BJUI, 2005)
- Usefulness of tamsulosin hydrochloride and naftopidil in patients with urinary disturbances caused by benign prostatic hyperplasia: A comparative, randomized, two-drug crossover study (International Journal of Urology, 2003)
- Clinical efficacy of an 1A/Dadrenoceptor blocker (naftopidil) on overactive bladder symptoms in patients with benign prostatic hyperplasia (International Journal of Urology, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
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SMILESCOC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
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InChIKeyHRRBJVNMSRJFHQ-UHFFFAOYSA-N
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- Wikipedia - naftopidil
Naftopidil (INN, marketed under the brand name Flivas) is a drug used in benign prostatic hypertrophy which acts as a selective 1-adrenergic receptor antagonist or alpha blocker.
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Synthesis
2-Methoxyphenylboronic acid
+
1-(Naphthalen-1-yloxy)-3-piperazin-1-yl-propan-2-ol
(Chan-Lam coupling reaction)
Reactant
+
1-(Chloromethoxy)naphthalene
(Grignard alcohol)
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naftopidil
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