| Weight | 203.207 g/mol |
|---|---|
| Formula | C10H12F3N |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
NORFENFLURAMINE (673-18-7, 1886-26-6)
Score:
#1077 in Neuroscience
,
#4670 in Biology
,
#5928 in Chemistry
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- Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors (Neuropharmacology, 2001)
- Differences Between dFenfluramine and dNorfenfluramine in Serotonin Presynaptic Mechanisms (Journal of Neurochemistry, 1983)
- d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors (European Journal of Pharmacology, 1993)
- The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine (Bioorganic & Medicinal Chemistry, 2007)
- Determination of fenfluramine and norfenfluramine in plasma using a nitrogen-sensitive detector. (Journal of Chromatography B: Biomedical Sciences and Applications, 1984)
- Impact of hypothalamic d-norfenfluramine and peripheral d-fenfluramine injection on macronutrient intake in the rat (Brain Research Bulletin, 1990)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(CC1=CC(=CC=C1)C(F)(F)F)N
-
InChIKeyMLBHFBKZUPLWBD-UHFFFAOYSA-N
- Pubchem - NORFENFLURAMINE
- Wikipedia - norfenfluramine
Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. This side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in Europe, as both fenfluramine and benfluorex form norfenfluramine as an active metabolite.
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