| Weight | 298.35 g/mol |
|---|---|
| Formula | C15H18N6O |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 6 |
olomoucine (101622-51-9)
NSC-666096 · ethanol, 2-((9-methyl-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-
Score:
#41 in Molecular and cellular biology
,
#726 in Neuroscience
,
#1310 in Biochemistry
,
#3206 in Biology
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- Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds (Journal of Medicinal Chemistry, 1997)
- Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine. (Proteins, 1995)
- The Cyclin-Dependent Kinase Inhibitors Olomoucine and Roscovitine Arrest Human Fibroblasts in G1 Phase by Specific Inhibition of CDK2 Kinase Activity (Experimental Cell Research, 1998)
- Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions (FEBS Letters, 1994)
- Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases (Biology of the Cell, 1995)
- In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202 (Clinical Cancer Research, 2005)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - NSC-666096
- ethanol, 2-((9-methyl-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-
-
SMILESCN1C=NC2=C1N=C(N=C2NCC3=CC=CC=C3)NCCO
-
InChIKeyGTVPOLSIJWJJNY-UHFFFAOYSA-N
- Pubchem - olomoucine
- Wikipedia - olomoucine
Glial scar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system. As with scarring in other organs and tissues, the glial scar is the body's mechanism to protect and begin the healing process in the nervous system. In the context of neurodegeneration, formation of the glial scar has been shown to have both beneficial and detrimental effects.
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olomoucine
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