| Weight | 447.543 g/mol |
|---|---|
| Formula | C24H29N7O2 |
| Hydrogen Acceptors | 9 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 5 |
Palbociclib (571190-30-2)
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- The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. (Lancet Oncology, 2015)
- Palbociclib in hormone-receptorpositive advanced breast cancer (The New England Journal of Medicine, 2015)
- Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial (Lancet Oncology, 2016)
- Palbociclib and Letrozole in Advanced Breast Cancer. (The New England Journal of Medicine, 2016)
- CDK 4/6 Inhibitor Palbociclib (PD0332991) in Rb+ Advanced Breast Cancer: Phase II Activity, Safety, and Predictive Biomarker Assessment (Clinical Cancer Research, 2015)
- FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer (Clinical Cancer Research, 2015)
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SMILESCC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C
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