| Weight | 205.265 g/mol |
|---|---|
| Formula | C10H15N5 |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
PHENFORMIN (114-86-3)
Fenformin · Phenylethylbiguanide
Score:
#24 in Molecular and cellular biology
,
#835 in Biochemistry
,
#2243 in Biology
,
#2760 in Chemistry
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- Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR (American Journal of Physiology-endocrinology and Metabolism, 2004)
- LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin (Cancer Cell, 2013)
- Effects of Hypoglycemic Agents on Vascular Complications in Patients With Adult-Onset Diabetes: IV. A Preliminary Report on Phenformin Results (JAMA, 1971)
- Effect of Treatment with Phenformin, Diphenylhydantoin or L-Dpa on Life Span and Tumour Incidence in C3H/Sn Mice (Gerontology, 1980)
- Reduction by phenformin of excessive insulin levels after glucose loading in obese and diabetic subjects. (Metabolism-clinical and Experimental, 1963)
- Phenformin and ethyloestrenol for Raynaud's disease. (The Lancet, 1969)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Fenformin
- Phenylethylbiguanide
-
SMILESC1=CC=C(C=C1)CCN=C(N)N=C(N)N
-
InChIKeyICFJFFQQTFMIBG-UHFFFAOYSA-N
- Pubchem - PHENFORMIN
- Wikipedia - phenformin
Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was discovered in 1957 by Ungar, Freedman and Seymour Shapiro, working for the US Vitamin Corporation.
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Synthesis
benzene
+
Reactant
(Friedel-Crafts alkylation)
Similar Compounds
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(101-54-2)
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(26148-68-5)
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(530-50-7)
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(92-69-3, 1322-20-9)
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(90-41-5)
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benzamidine
(618-39-3)
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1-Phenylurea
(64-10-8)
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(1943-82-4)
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(101-18-8)
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(492-17-1)
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86-93-1
(86-93-1)
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2-Amino-2-phenylacetic acid
(69-91-0, 2835-06-5)
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(584-84-9, 86-91-9, 26006-20-2)
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5 safety hazards
3 suppliers
2-Phenylphenol
(61788-42-9, 90-43-7)
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3 safety hazards
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(92-52-4, 68409-73-4)
3 alternate names
6 safety hazards
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(86-88-4)
3 alternate names
1 safety hazard
3 suppliers
Diphenyl oxide
(101-84-8)
3 alternate names
2 safety hazards
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Diphenylamine
(68442-68-2, 122-39-4)
3 alternate names
6 safety hazards
3 suppliers
2-CHLOROBIPHENYL
(27323-18-8, 11097-69-1, 2051-60-7, 53469-21-9)
3 alternate names
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THIDIAZURON
(51707-55-2)
3 alternate names
3 suppliers
6-Benzylaminopurine
(1214-39-7)
3 alternate names
4 safety hazards
3 suppliers
1,5-Diaminonaphthalene
(2243-62-1)
3 alternate names
5 safety hazards
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BENZOTRIFLUORIDE
(98-08-8)
3 alternate names
2 safety hazards
3 suppliers
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(55-21-0)
3 alternate names
3 suppliers
GUANFACINE
(29110-47-2)
3 alternate names
3 suppliers
2-AMINOBENZAMIDE
(88-68-6)
3 alternate names
3 suppliers
CINNAMIC ACID
(621-82-9, 9045-22-1, 140-10-3, 63938-16-9)
3 alternate names
3 suppliers
Phenyl isocyanide dichloride
(622-44-6)
3 alternate names
3 suppliers
Benzohydrazide
(613-94-5)
3 alternate names
3 suppliers
PHENOXYACETIC ACID
(122-59-8)
3 alternate names
3 suppliers
N-Phenylmaleimide
(941-69-5)
3 alternate names
1 safety hazard
3 suppliers
4-CHLOROBIPHENYL
(2051-62-9)
3 alternate names
3 suppliers
4-BROMOBIPHENYL
(92-66-0)
3 alternate names
3 suppliers
PHENYLACETYL CHLORIDE
(103-80-0)
3 alternate names
3 suppliers
sulfaguanidine
(57-67-0)
3 alternate names
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Indole-2-carboxylic acid
(1477-50-5)
3 alternate names
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(4561-43-7, 7568-93-6)
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3 suppliers
Benzenesulfonohydrazide
(80-17-1)
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benzyl isothiocyanate
(622-78-6)
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(321-60-8)
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Betamipron
(3440-28-6)
3 alternate names
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(103-29-7, 38888-98-1)
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(2236-60-4)
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(326-43-2, 553-69-5)
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3 suppliers
N,N'-Diphenylmethylenediamine
(101-77-9, 622-14-0)
3 alternate names
3 suppliers
DL-o-Tyrosine
(2370-61-8, 709-16-0)
3 alternate names
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2-AMINO-4-CHLOROBENZOTHIAZOLE
(19952-47-7)
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(637-44-5)
3 alternate names
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Benzidine
(92-87-5)
3 alternate names
5 safety hazards
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4,4'-Methylenedianiline
(13552-44-8, 101-77-9)
3 alternate names
4 safety hazards
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cinnamaldehyde
(14371-10-9, 104-55-2, 57194-69-1)
3 alternate names
3 suppliers
2-Aminonaphthalene
(91-59-8)
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3 suppliers
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(532-27-4)
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(104-55-2)
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2-Propenal, 3-phenyl-
(104-55-2)
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