| Weight | 265.338 g/mol |
|---|---|
| Formula | C12H15N3O2S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Protein kinase inhibitor H-8 (84478-11-5)
H8 protein kinase inhibitor · N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide · H-8 protein kinase inhibitor
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- Systemic Administration of Calmodulin Antagonist W-7 or Protein Kinase A Inhibitor H-8 Prevents Torsade de Pointes in Rabbits (Circulation, 1999)
- Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase. (Molecular Pharmacology, 1987)
- Blockade of the spinal excitatory effect of cAMP on the startle reflex by intrathecal administration of the isoquinoline sulfonamide H-8: comparison to the protein kinase C inhibitor H-7 (Brain Research, 1990)
- Inhibition of lipopolysaccharide-induced transcription factor Sp1 binding by spectrally pure diphosphoryl lipid A from Rhodobacter sphaeroides, protein kinase inhibitor H-8, and dexamethasone. (Infection and Immunity, 1997)
- Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel -subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor (Neuroscience Letters, 1997)
- Potentiation of oncogenic N-ras-induced neurite outgrowth and ornithine decarboxylase activity by phorbol dibutyrate and protein kinase inhibitor H-8. (Journal of Cellular Physiology, 1990)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H8 protein kinase inhibitor
- N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide
- H-8 protein kinase inhibitor
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SMILESCNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2
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Protein kinase inhibitor H-8
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