Propyl 4-hydroxybenzoate (94-13-3)

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Most-cited Publications

• Simultaneous determination of preservatives (benzoic acid, sorbic acid, methylparaben and propylparaben) in foodstuffs using high-performance liquid chromatography (Journal of Chromatography A, 2005)
• Advanced Oxidation Kinetics and Mechanism of Preservative Propylparaben Degradation in Aqueous Suspension of TiO2 and Risk Assessment of Its Degradation Products (Environmental Science & Technology, 2013)
• Simultaneous determination of methylparaben, propylparaben and thimerosal by high-performance liquid chromatography and electrochemical detection. (Journal of Pharmaceutical and Biomedical Analysis, 1997)
• Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro. (Antimicrobial Agents and Chemotherapy, 1995)
• Simultaneous determination of methylparaben, propylparaben, sodium diclofenac and its degradation product in a topical emulgel by reversed-phase liquid chromatography (Analytica Chimica Acta, 2002)
• A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation (Journal of Pharmaceutical and Biomedical Analysis, 2005)

Areas of Application

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Trends

Alternate Names

• propylparaben
• PEPH
• Bayer D 206
• p-hydroxybenzoic acid propyl ester
• Nipazol
• 4-hydroxybenzoic acid propyl ester
• propylparaben, monosodium salt
• 3(or 4)-hydroxybenzoic acid propyl ester
• propyl p-hydroxybenzoate
• SMILES
  CCCOC(=O)C1=CC=C(C=C1)O
• InChIKey
  QELSKZZBTMNZEB-UHFFFAOYSA-N

External Links

• Pubchem - Propyl 4-hydroxybenzoate
• Wikipedia - propylparaben
  Propylparaben, the n-propyl ester of p-hydroxybenzoic acid, occurs as a natural substance found in many plants and some insects, although it is manufactured synthetically for use in cosmetics, pharmaceuticals and foods. It is a preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. As a food additive, it has the E number E216.

Synthesis

4-HYDROXYBENZOIC ACID  +  1-CHLOROPROPANE (Ester from carboxilic acid(SN2))

Reactant  +  dimethyl sulfide (Corey-Kim oxidation of secondary alcohols)

Synthesis of Propyl 4-hydroxybenzoate ›

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Propyl 4-hydroxybenzoate

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