| Weight | 303.337 g/mol |
|---|---|
| Formula | C16H18FN3O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Retigabine (150812-12-7)
Score:
#50 in Neurology
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#257 in Neuroscience
,
#1172 in Biology
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- Sigma-Aldrich - Retigabine91.80 - 370.50 USD
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- Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. (The Journal of Neuroscience, 2001)
- Retigabine, A Novel Anti-Convulsant, Enhances Activation of KCNQ2/Q3 Potassium Channels (Molecular Pharmacology, 2000)
- Modulation of KCNQ2/3 Potassium Channels by the Novel Anticonvulsant Retigabine (Molecular Pharmacology, 2000)
- The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits (Neuroscience Letters, 2000)
- The New Anticonvulsant Retigabine Favors Voltage-Dependent Opening of the Kv7.2 (KCNQ2) Channel by Binding to Its Activation Gate (Molecular Pharmacology, 2005)
- The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. (European Journal of Pharmacology, 2003)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N
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- Pubchem - Retigabine
- Wikipedia - ezogabine
Retigabine or ezogabine is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. The drug was developed by Valeant Pharmaceuticals and GlaxoSmithKline. It was approved by the European Medicines Agency under the trade name Trobalt on March 28, 2011, and by the United States Food and Drug Administration (FDA), under the trade name Potiga, on June 10, 2011.
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Retigabine
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