| Weight | 348.443 g/mol |
|---|---|
| Formula | C19H28N2O4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 9 |
ROXATIDINE ACETATE (78628-28-1)
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- Cytoprotective action of roxatidine acetate HCl. (Archives internationales de pharmacodynamie et de thrapie, 1988)
- Roxatidine acetate : a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders (Drugs, 1991)
- A Pharmacokinetic Study of Roxatidine Acetate in Chronic Renal Failure (Drugs, 1988)
- The metabolism of roxatidine acetate hydrochloride: liberation of deuterium from the piperidine ring during hydroxylation (Drug Metabolism and Disposition, 1987)
- A comparison of the inhibitory effects of roxatidine acetate hydrochloride and cimetidine on cytochrome P-450-mediated drug-metabolism in mouse hepatic microsomes and in man in vivo. (Journal of pharmacobio-dynamics, 1987)
- A Review of the Animal Pharmacology of Roxatidine Acetate (Drugs, 1988)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2
-
InChIKeySMTZFNFIKUPEJC-UHFFFAOYSA-N
- Pubchem - ROXATIDINE ACETATE
- Wikipedia - roxatidine acetate
Roxatidine acetate is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, ZollingerEllison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis. Pharmacodynamic studies showed that 150mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150mg was more effective than a dose of 75mg twice daily in terms of inhibiting nocturnal acid secretion. It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece and South Africa.
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