Weight | 186.186 g/mol |
---|---|
Formula | C10H11NaO2 |
Hydrogen Acceptors | 2 |
Hydrogen Donors | 0 |
Aromatic Rings | 1 |
Rotatable Bonds | 4 |
Sodium 4-phenylbutyrate (1716-12-7, 2686-71-7)
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- Sigma-Aldrich - Sodium 4-phenylbutyrate68.50 - 338.10 USD
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- In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. (Journal of Clinical Investigation, 1997)
- A Pilot Clinical Trial of Oral Sodium 4-Phenylbutyrate (Buphenyl) in F508-Homozygous Cystic Fibrosis Patients (American Journal of Respiratory and Critical Care Medicine, 1998)
- Sodium 4-Phenylbutyrate Protects against Cerebral Ischemic Injury (Molecular Pharmacology, 2004)
- Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of F508-CFTR (American Journal of Physiology-cell Physiology, 2000)
- Increased fetal hemoglobin in patients receiving sodium 4-phenylbutyrate. (The New England Journal of Medicine, 1992)
- Sodium 4-Phenylbutyrate Acts as a Chemical Chaperone on Misfolded Myocilin to Rescue Cells from Endoplasmic Reticulum Stress and Apoptosis (Investigative Ophthalmology & Visual Science, 2007)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
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InChIKeyVPZRWNZGLKXFOE-UHFFFAOYSA-M
- Pubchem - Sodium 4-phenylbutyrate
- Wikipedia - sodium phenylbutyrate
Sodium phenylbutyrate is a salt of an aromatic fatty acid, 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid. The compound is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen. It is an orphan drug, marketed by Ucyclyd Pharma under the trade name Buphenyl, by Swedish Orphan International (Sweden) as Ammonaps, and by Fyrlklvern Scandinavia as triButyrate.
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