| Weight | 408.52 g/mol |
|---|---|
| Formula | C20H28N2O5S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 11 |
TAMSULOSIN (106133-20-4)
Score:
#1180 in Biology
,
#1349 in Chemistry
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- Tolterodine and Tamsulosin for Treatment of Men With Lower Urinary Tract Symptoms and Overactive Bladder: A Randomized Controlled Trial (JAMA, 2006)
- The Effects of Combination Therapy with Dutasteride and Tamsulosin on Clinical Outcomes in Men with Symptomatic Benign Prostatic Hyperplasia: 4-Year Results from the CombAT Study (European Urology, 2010)
- Intraoperative floppy iris syndrome associated with tamsulosin. (Journal of Cataract and Refractive Surgery, 2005)
- Phase III Multicenter Placebo-Controlled Study of Tamsulosin in Benign Prostatic Hyperplasia (Urology, 1998)
- EFFICACY OF TAMSULOSIN IN THE MEDICAL MANAGEMENT OF JUXTAVESICAL URETERAL STONES (The Journal of Urology, 2003)
- The Effects of Dutasteride, Tamsulosin and Combination Therapy on Lower Urinary Tract Symptoms in Men With Benign Prostatic Hyperplasia and Prostatic Enlargement: 2-Year Results From the CombAT Study (The Journal of Urology, 2008)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N
-
InChIKeyDRHKJLXJIQTDTD-UHFFFAOYSA-N
- Pubchem - TAMSULOSIN
- Wikipedia - tamsulosin
Tamsulosin, sold under the trade name Alna / Flomax , is a medication used to treat symptomatic benign prostatic hyperplasia (BPH), help with the passage of kidney stones, and for urinary retention along with other measures. Tamsulosin, and other medications in the class called alpha blockers, work by relaxing bladder neck muscles and muscle fibers in the prostate itself and make it easier to urinate. It is an 1a adrenergic receptor antagonist.
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Synthesis
5-(2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE
+
1-(2-CHLOROETHOXY)-2-ETHOXYBENZENE
(Alkylation of primary amines)
2-Ethoxyphenol
+
Reactant
(Williamson ether)
2-methoxybenzenesulfonamide
+
Reactant
(Friedel-Crafts alkylation)
2-ETHOXYBENZALDEHYDE
+
Reactant
(Dakin oxidation)
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