| Weight | 178.151 g/mol |
|---|---|
| Formula | C7H6N4O2 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 0 |
TIRAPAZAMINE (27314-97-2)
Score:
#1572 in Physics
,
#1686 in Biochemistry
,
#4748 in Chemistry
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- Prognostic Significance of [18F]-Misonidazole Positron Emission TomographyDetected Tumor Hypoxia in Patients With Advanced Head and Neck Cancer Randomly Assigned to Chemoradiation With or Without Tirapazamine: A Substudy of Trans-Tasman Radiation Oncology Group Study 98.02 (Journal of Clinical Oncology, 2006)
- SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. (British Journal of Cancer, 1993)
- Tirapazamine Plus Cisplatin Versus Cisplatin in Advanced NonSmall-Cell Lung Cancer: A Report of the International CATAPULT I Study Group (Journal of Clinical Oncology, 2000)
- Tirapazamine, Cisplatin, and Radiation Versus Fluorouracil, Cisplatin, and Radiation in Patients With Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02) (Journal of Clinical Oncology, 2005)
- Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group (Journal of Clinical Oncology, 2010)
- Phase I Trial of Concurrent Tirapazamine, Cisplatin, and Radiotherapy in Patients With Advanced Head and Neck Cancer (Journal of Clinical Oncology, 2001)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=C2C(=C1)N(C(=N)N=[N+]2[O-])O
-
InChIKeyQVMPZNRFXAKISM-UHFFFAOYSA-N
- Pubchem - TIRAPAZAMINE
- Wikipedia - Tirapazamine
Tirapazamine (SR-4233) is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia. Thus, tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors.
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TIRAPAZAMINE
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