| Weight | 448.95 g/mol |
|---|---|
| Formula | C26H25ClN2O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 3 |
Tolvaptan (150683-30-0)
Score:
#3 in Medicinal chemistry
,
#320 in Biochemistry
,
#1170 in Biology
,
#1336 in Chemistry
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- Sigma-Aldrich - Tolvaptan87.90 - 372.00 USD
- Fisher Scientific - Search for Tolvaptan
- TCI - Search for Tolvaptan
- Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure: The EVEREST Outcome Trial (JAMA, 2007)
- Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. (The New England Journal of Medicine, 2006)
- Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials. (JAMA, 2007)
- Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. (JAMA, 2004)
- Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (The New England Journal of Medicine, 2012)
- Vasopressin V2-Receptor Blockade With Tolvaptan in Patients With Chronic Heart Failure Results From a Double-Blind, Randomized Trial (Circulation, 2003)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
-
InChIKeyGYHCTFXIZSNGJT-UHFFFAOYSA-N
- Pubchem - Tolvaptan
- Wikipedia - tolvaptan
Tolvaptan (INN, trade names Samsca and Jinarc) is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U.S. Food and Drug Administration (FDA) on May 19, 2009, and is sold by Otsuka Pharmaceutical Co.
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