Score: #21 in Molecular and cellular biology , #687 in Biochemistry , #1926 in Biology , #2337 in Chemistry

  Anti-diabetic drug · Antiandrogen · Antiglucocorticoid · Antineoplastic and immunomodulating drug · Antineoplastic drug · Aromatase inhibitor · CYP17A1 inhibitor · Drugs acting on the gastrointestinal system and metabolism · Drugs acting on the genito-urinary system · Hormonal agent · Hormonal antineoplastic drug · PPAR agonist · Pharmaceutical · Sex hormone · Systemic hormonal preparation · Thiazolidinedione

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• Sigma-Aldrich - troglitazone
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• Fisher Scientific - Search for troglitazone
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Most-cited Publications

• Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. (Journal of Clinical Investigation, 1998)
• Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone (The New England Journal of Medicine, 1994)
• Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus (The New England Journal of Medicine, 1998)
• Ligand for Peroxisome Proliferator-activated Receptor (Troglitazone) Has Potent Antitumor Effect against Human Prostate Cancer Both in Vitro and in Vivo (Cancer Research, 1998)
• The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome (The Journal of Clinical Endocrinology and Metabolism, 1996)
• Troglitazone Improves Ovulation and Hirsutism in the Polycystic Ovary Syndrome: A Multicenter, Double Blind, Placebo-Controlled Trial (The Journal of Clinical Endocrinology and Metabolism, 2001)

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Alternate Names

• SMILES
  CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O
• InChIKey
  GXPHKUHSUJUWKP-UHFFFAOYSA-N

External Links

• Pubchem - troglitazone
• Wikipedia - Troglitazone
  Troglitazone (Rezulin, Resulin, Romozin, Noscal) is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for patients with diabetes mellitus type 2. It was developed by Daiichi Sankyo (Japan).

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