| Weight | 356.51 g/mol |
|---|---|
| Formula | C22H32N2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 4 |
U-69593 (96744-75-1)
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- Sigma-Aldrich - U-69593168.50 - 607.00 USD
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- [3H]U-69593 a highly selective ligand for the opioid receptor (European Journal of Pharmacology, 1985)
- The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat (Brain Research, 1993)
- The KOpioid Agonist, U69593, Decreases Acute AmphetamineEvoked Behaviors and CalciumDependent Dialysate Levels of Dopamine and Glutamate in the Ventral Striatum (Journal of Neurochemistry, 2001)
- Autoradiography of [3H]U-69593 binding sites in rat brain: evidence for opioid receptor subtypes (European Journal of Pharmacology, 1988)
- U-69593 prevents cocaine sensitization by normalizing basal accumbens dopamine. (Neuroreport, 1994)
- [3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine (Life Sciences, 1988)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN(C1CCC2(CCCO2)CC1N3CCCC3)C(=O)CC4=CC=CC=C4
-
InChIKeyPGZRDDYTKFZSFR-UHFFFAOYSA-N
- Pubchem - U-69593
- Wikipedia - u-69593
U-69,593 is a drug which acts as a potent and selective 1-opioid receptor agonist. In animal studies it has been shown to produce antinociception, anti-inflammation, anxiolysis (at low doses), respiratory depression, and diuresis, while having little effect on gastrointestinal motility. It also inhibits the peripheral, though not central secretion of oxytocin and vasopressin in rats.
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