| Weight | 387.484 g/mol |
|---|---|
| Formula | C20H29N5O3 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 7 |
urapidil (34661-75-1)
urapidil, 2,3-(14)C2-labeled · 6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil · urapidil monohydrochloride
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- Subclassification of 1-adrenoceptor recognition sites by urapidil derivatives and other selective antagonists (British Journal of Pharmacology, 1989)
- 5-Methyl-urapidil discriminates between subtypes of the 1-adrenoceptor (European Journal of Pharmacology, 1988)
- Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for 1-adrenoceptor binding sites (Naunyn-schmiedebergs Archives of Pharmacology, 1987)
- CENTRAL 5-HT1A RECEPTORS AND THE MECHANISM OF THE CENTRAL HYPOTENSIVE EFFECT OF (+)8-OH-DPAT, DP-5-CT, R28935, AND URAPIDIL (Journal of Cardiovascular Pharmacology, 1988)
- Investigations on the mode of action of a new antihypertensive drug, urapidil, in the isolated rat vas deferens (European Journal of Pharmacology, 1979)
- A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic Shivering (Anesthesia & Analgesia, 2000)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - urapidil, 2,3-(14)C2-labeled
- 6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil
- urapidil monohydrochloride
- urapidil, 5-(14)C-labeled
- Ebrantil
-
SMILESCN1C(=CC(=O)N(C1=O)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC
-
InChIKeyICMGLRUYEQNHPF-UHFFFAOYSA-N
- Pubchem - urapidil
- Wikipedia - urapidil
Urapidil is a sympatholytic antihypertensive drug. It acts as an 1-adrenoceptor antagonist and as an 5-HT1A receptor agonist. Although an initial report suggested that urapidil was also an 2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum.
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Synthesis
6-Amino-1,3-dimethyluracil
+
1-(3-Chloropropyl)-4-(2-methoxyphenyl)piperazine
(Alkylation of primary amines)
2-Methoxyphenylboronic acid
+
Reactant
(Chan-Lam coupling reaction)
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urapidil
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