Weight | 394.69 g/mol |
---|---|
Formula | C14H18Cl3N5O2 |
Hydrogen Acceptors | 7 |
Hydrogen Donors | 2 |
Aromatic Rings | 1 |
Rotatable Bonds | 6 |
WR99210 (30711-93-4, 47326-86-3)
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- Sigma-Aldrich - WR99210123.50 - 499.00 USD
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- Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil (Proceedings of the National Academy of Sciences of the United States of America, 1997)
- Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: Structural basis of antifolate resistance (Bioorganic & Medicinal Chemistry, 2000)
- Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax (Proceedings of the National Academy of Sciences of the United States of America, 2002)
- Novel Saccharomyces cerevisiae Screen Identifies WR99210 Analogues That Inhibit Mycobacterium tuberculosis Dihydrofolate Reductase (Antimicrobial Agents and Chemotherapy, 2002)
- Plasmodium falciparum : Kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase (Experimental Parasitology, 1997)
- The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug. (American Journal of Tropical Medicine and Hygiene, 1999)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1(N=C(N=C(N1OCCCOC2=CC(=C(C=C2Cl)Cl)Cl)N)N)C
-
InChIKeyMJZJYWCQPMNPRM-UHFFFAOYSA-N
- Pubchem - WR99210
- Wikipedia - 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine
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