| Weight | 236.296 g/mol |
|---|---|
| Formula | C11H12N2O2S |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
ZILEUTON (111406-87-2)
Score:
#890 in Biochemistry
,
#2369 in Biology
,
#2935 in Chemistry
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- 5-lipoxygenase inhibitory activity of zileuton. (Journal of Pharmacology and Experimental Therapeutics, 1991)
- Benefits from adding the 5-lipoxygenase inhibitor Zileuton to conventional therapy in aspirin-intolerant asthmatics (American Journal of Respiratory and Critical Care Medicine, 1998)
- The Effect of Inhibition of 5-Lipoxygenase by Zileuton in Mild-to-Moderate Asthma (Annals of Internal Medicine, 1993)
- Effect of Treatment With Zileuton, a 5-Lipoxygenase Inhibitor, in Patients With Asthma: A Randomized Controlled Trial (JAMA, 1996)
- Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. (JAMA, 1996)
- Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. (American Journal of Respiratory and Critical Care Medicine, 1996)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O
-
InChIKeyMWLSOWXNZPKENC-UHFFFAOYSA-N
- Pubchem - ZILEUTON
- Wikipedia - zileuton
Zileuton (trade name ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used for the maintenance treatment of asthma. Zileuton was introduced in 1996 by Abbott Laboratories and is now marketed in two formulations by Cornerstone Therapeutics Inc. under the brand names ZYFLO and ZYFLO CR.
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