| Weight | 286.371 g/mol |
|---|---|
| Formula | C18H22O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
16alpha-Hydroxyestrone (566-76-7)
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- Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine. (Environmental Health Perspectives, 1997)
- Predictors of the plasma ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone among pre-menopausal, nulliparous women from four ethnic groups. (Carcinogenesis, 2003)
- Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells (Journal of Molecular Endocrinology, 2001)
- Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens. (Environmental Health Perspectives, 1998)
- Tissue-selective effects of continuous release of 2-hydroxyestrone and 16alpha-hydroxyestrone on bone, uterus and mammary gland in ovariectomized growing rats. (Journal of Endocrinology, 2001)
- [Physiological and therapeutic action of 16alpha-hydroxyestrone]. (Therapie, 1961)
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SMILESCC12CCC3C(C1CC(C2=O)O)CCC4=C3C=CC(=C4)O
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InChIKeyWPOCIZJTELRQMF-UHFFFAOYSA-N
- Pubchem - 16alpha-Hydroxyestrone
- Wikipedia - 16-hydroxyestrone
16-Hydroxyestrone (16-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol. It is a potent estrogen similarly to estrone, and it has been suggested that the ratio of 16-hydroxyestrone to 2-hydroxyestrone, the latter being much less estrogenic in comparison and even antiestrogenic in the presence of more potent estrogens like estradiol, may be involved in the pathophysiology of breast cancer. Conversely, 16-hydroxyestrone may help to protect against osteoporosis.
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