| Weight | 286.371 g/mol |
|---|---|
| Formula | C18H22O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
2-HYDROXYESTRONE (362-06-1)
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- Estrogen metabolism and risk of breast cancer: A prospective study of the 2:16-hydroxyestrone ratio in premenopausal and postmenopausal women (Epidemiology, 2000)
- Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells. (Journal of Biological Chemistry, 1984)
- Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk. (Environmental Health Perspectives, 1995)
- 2-Hydroxyestrone: the 'good' estrogen (Journal of Endocrinology, 1996)
- Urinary 2-Hydroxyestrone/16-Hydroxyestrone Ratio and Risk of Breast Cancer in Postmenopausal Women (Journal of the National Cancer Institute, 1999)
- Increased urinary excretion of 2-hydroxyestrone but not 16-hydroxyestrone in premenopausal women during a soya diet containing isoflavones. (Cancer Research, 2000)
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SMILESCC12CCC3C(C1CCC2=O)CCC4=CC(=C(C=C34)O)O
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InChIKeySWINWPBPEKHUOD-UHFFFAOYSA-N
- Pubchem - 2-HYDROXYESTRONE
- Wikipedia - 2-hydroxyestrone
2-Hydroxyestrone (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a major metabolite of estrone and estradiol. It is formed irreversibly from estrone in the liver and to a lesser extent in other tissues via 2-hydroxylation mediated by cytochrome P450 enzymes, mainly the CYP3A and CYP1A subfamilies. 2-OHE1 is the most abundant catechol estrogen in the body.
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