Weight | 222.248 g/mol |
---|---|
Formula | C10H14N4O2 |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 1 |
Aromatic Rings | 2 |
Rotatable Bonds | 2 |
3-Isobutyl-1-methylxanthine (28822-58-4)
IBMX · Isobutyltheophylline · 1-Methyl-3-isobutylxanthine
Score:
#1328 in Biochemistry
,
#3240 in Biology
,
#4049 in Chemistry
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- Sigma-Aldrich - 3-Isobutyl-1-methylxanthine37.40 - 669.00 USD
- Fisher Scientific - Search for 3-Isobutyl-1-methylxanthine
- TCI - Search for 3-Isobutyl-1-methylxanthine
- Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity (Journal of Biological Chemistry, 2004)
- Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells (International Journal of Cancer, 1991)
- Dopamine Inhibits Forskolin- and 3-Isobutyl-1-Methylxanthine-Induced Dark-Adaptive Retinomotor Movements in Isolated Teleost Retinas (Journal of Neurochemistry, 1985)
- Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. (Proceedings of the National Academy of Sciences of the United States of America, 2004)
- Effects of cAMP and IBMX on the Chick Retinal Pigment Epithelium Membrane Potentials and Light-Evoked Responses (Investigative Ophthalmology & Visual Science, 1990)
- Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells (PLOS ONE, 2010)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - IBMX
- Isobutyltheophylline
- 1-Methyl-3-isobutylxanthine
- 3 Isobutyl 1 methylxanthine
- 1 Methyl 3 isobutylxanthine
-
SMILESCC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
-
InChIKeyAPIXJSLKIYYUKG-UHFFFAOYSA-N
- Pubchem - 3-Isobutyl-1-methylxanthine
- Wikipedia - isobutylmethylxanthine
IBMX (3-isobutyl-1-methylxanthine), like other methylated xanthine derivatives, is both a: non-competitive selective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity, and nonselective adenosine receptor antagonist. As a phosphodiesterase inhibitor, IBMX has IC50 = 250 M and does not inhibit PDE8 or PDE9.
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