| Weight | 258.234 g/mol |
|---|---|
| Formula | C9H14N4O5 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
ACADESINE (2627-69-2)
AICA riboside · AICA ribonucleoside · ARA-100
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- AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle (American Journal of Physiology-endocrinology and Metabolism, 1997)
- Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle (Diabetes, 2002)
- Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury. (Circulation, 1989)
- Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes (Diabetes, 1991)
- Effects of Acadesine on Myocardial Infarction, Stroke, and Death Following Surgery: A Meta-analysis of the 5 International Randomized Trials (JAMA, 1997)
- Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes (Blood, 2003)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - AICA riboside
- AICA ribonucleoside
- ARA-100
- 5-aminoimidazole-4-carboxamide 1-ribofuranoside
- AICA ribofuranoside
- ARA 100
- 5-aminoimidazole-4-carboxamide riboside
- Z-riboside
- arasine
- ARA100
- GP 1 110
- aminoimidazole carboxamide ribonucleoside
- 1-ribosyl-4-carboxamido-5-aminoimidazole
-
SMILESC1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N
-
InChIKeyRTRQQBHATOEIAF-UHFFFAOYSA-N
- Pubchem - ACADESINE
- Wikipedia - acadesine
Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1--D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery.
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ACADESINE
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