| Weight | 458.581 g/mol |
|---|---|
| Formula | C28H31FN4O |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 4 |
| Rotatable Bonds | 8 |
astemizole (68844-77-9)
Hismanal · Romadin · Elfar Brand of Astemizole
Score:
#4 in Medicinal chemistry
,
#335 in Biochemistry
,
#1239 in Biology
,
#1426 in Chemistry
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- Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy. (Drugs, 1984)
- Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. (FEBS Letters, 1996)
- Cardiac Electrophysiological Actions of the Histamine H1-Receptor Antagonists Astemizole and Terfenadine Compared With Chlorpheniramine and Pyrilamine (Circulation Research, 1995)
- A clinical drug library screen identifies astemizole as an antimalarial agent. (Nature Chemical Biology, 2006)
- Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. (Journal of Cardiovascular Electrophysiology, 1999)
- A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: Suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects (The Journal of Allergy and Clinical Immunology, 1990)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Hismanal
- Romadin
- Elfar Brand of Astemizole
- Astemizole Esteve Brand
- Hubermizol
- Astemizole Smaller Brand
- Fustery Brand of Astemizole
- Janssen Brand of Astemizole
- Astemizole Elfar Brand
- Astemizol Alonga
- Diba Brand of Astemizole
- Merck Brand of Astemizole
- R43512
- ICN Brand of Astemizole
- Alacan Brand of Astemizole
- Astemizole Septa Brand
- Astemizole Byk Brand
- Fustermizol
- Astemizole Janssen Brand
- Smaller Brand of Astemizole
- Vita Brand of Astemizole
- Astemizole Alonga Brand
- Astemizole Senosiain Brand
- Astemizole Fustery Brand
- Medinsa Brand of Astemizole
- Astemizole Medinsa Brand
- Astemizole McNeil Brand
- Esteve Brand of Astemizole
- Laridal
- Urbion Brand of Astemizole
- Rimbol
- Emdar
- Alonga Brand of Astemizole
- Astemina
- R 43 512
- Rifedot
- Senosiain Brand of Astemizole
- Byk Brand of Astemizole
- Paralergin
- Septa Brand of Astemizole
- Simprox
- Histaminos
- Astemizole Merck Brand
- Alermizol
- Astemizole Lesvi Brand
- Astemizole Vita Brand
- Reig Jofre Brand of Astemizole
- Astemizole ratiopharm Brand
- Retolen
- Urdrim
- Astemizole Urbion Brand
- Astemizole Diba Brand
- Esmacen
- Astemizol ratiopharm
- Astemizole Alacan Brand
- McNeil Brand of Astemizole
- Astesen
- Astemizole ICN Brand
- R-43-512
- ratiopharm Brand of Astemizole
- Lesvi Brand of Astemizole
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SMILESCOC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
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InChIKeyGXDALQBWZGODGZ-UHFFFAOYSA-N
- Pubchem - astemizole
- Wikipedia - astemizole
Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade).
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astemizole
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