Weight | 558.65 g/mol |
---|---|
Formula | C33H35FN2O5 |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 4 |
Aromatic Rings | 4 |
Rotatable Bonds | 12 |
atorvastatin
134523-00-5, 110862-48-1, 134523-03-8
Score:
#35 in Biochemistry
,
#38 in Neuroscience
,
#202 in Biology
,
#211 in Chemistry
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- Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes TrialLipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial (The Lancet, 2003)
- Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial (The Lancet, 2004)
- Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease (The New England Journal of Medicine, 2005)
- Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes. The MIRACL study : A randomized controlled trial. (JAMA, 2001)
- Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis (The New England Journal of Medicine, 2005)
- High-dose atorvastatin after stroke or transient ischemic attack. (The New England Journal of Medicine, 2006)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
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- Pubchem - atorvastatin
- Wikipedia - atorvastatin
Atorvastatin, marketed under the trade name Lipitor among others, is a member of the medication class known as statins, which are used primarily as a lipid-lowering agent and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Atorvastatin was first made in August 1985 at Warner-Lambert's Parke-Davis research facility in Ann Arbor, Michigan by a team led by Bruce Roth.
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