| Weight | 271.788 g/mol |
|---|---|
| Formula | C14H22ClNO2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
BUPRANOLOL (23284-25-5, 14556-46-8)
KL-255 · Betadrenol · KL 255
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- Influence of Supersaturation on the Pharmacodynamic Effect of Bupranolol After Dermal Administration Using Microemulsions as Vehicle (Pharmaceutical Research, 1992)
- A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a Schild-plot with apparent slope unity. Agonist-dependent enantiomeric affinity ratios for bupranolol in tracheae but not in right atria of guinea pigs. (Naunyn-schmiedebergs Archives of Pharmacology, 1983)
- Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin (International Journal of Pharmaceutics, 2004)
- Effect of penetration enhancers on the release and skin permeation of bupranolol from reservoir-type transdermal delivery systems (International Journal of Pharmaceutics, 2005)
- Role of -Adrenergic Receptors in the Effect of the -Adrenergic Receptor Ligands, CGP 12177, Bupranolol, and SR 59230A, on the Contraction of Rat Intrapulmonary Artery (Journal of Pharmacology and Experimental Therapeutics, 2004)
- The intraocular pressure response of glaucomatous eyes to topically applied bupranolol. A pilot study. (Graefes Archive for Clinical and Experimental Ophthalmology, 1977)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - KL-255
- Betadrenol
- KL 255
- KL255
-
SMILESCC1=CC(=C(C=C1)Cl)OCC(CNC(C)(C)C)O
-
InChIKeyHQIRNZOQPUAHHV-UHFFFAOYSA-N
- Pubchem - BUPRANOLOL
- Wikipedia - bupranolol
Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity. Its potency is similar to propranolol.
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Synthesis
tert-Butylamine
+
Reactant
(Alkylation of primary amines)
Reactant
+
CID 14898551
(Chan-Lam coupling reaction)
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