| Weight | 290.747 g/mol |
|---|---|
| Formula | C12H19ClN2O4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
MIDODRINE HYDROCHLORIDE (43218-56-0)
Midodrine · Midon · ProAmatine
Score:
#177 in Neurology
,
#785 in Neuroscience
,
#3456 in Biology
,
#4316 in Chemistry
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- Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide (Hepatology, 1999)
- Efficacy of Midodrine vs Placebo in Neurogenic Orthostatic Hypotension: A Randomized, Double-blind Multicenter Study (JAMA, 1997)
- Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndrome (Hepatology, 2004)
- Neurogenic orthostatic hypotension: A double-blind, placebo-controlled study with midodrine (The American Journal of Medicine, 1993)
- A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension (Neurology, 1998)
- Midodrine: a role in the management of neurocardiogenic syncope (Heart, 1998)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Midodrine
- Midon
- ProAmatine
- Amatine
- Gutron
- Midodrine Monohydrochloride
- Midodrin
- ST1085
- ST 1085
- ST-1085
-
SMILESCOC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O.Cl
-
InChIKeyMGCQZNBCJBRZDT-UHFFFAOYSA-N
- Pubchem - MIDODRINE HYDROCHLORIDE
- Wikipedia - midodrine hydrochloride
Midodrine (brand names Amatine, ProAmatine, Gutron, Bramox)is a vasopressor/antihypotensive agent. Midodrine was approved in the United States by the Food and Drug Administration (FDA) in 1996 for the treatment of dysautonomia and orthostatic hypotension. In August 2010, the FDA proposed withdrawing this approval because the manufacturer, Shire plc, has failed to complete required studies after the medicine reached the market.
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Synthesis
Reactant
+
2-Chloro-1,4-dimethoxybenzene
(Grignard alcohol)
1,4-Dimethoxybenzene
+
Reactant
(Friedel-Crafts alkylation)
Reactant
+
Methyl hydroperoxide
(Dakin oxidation)
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MIDODRINE HYDROCHLORIDE
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