| Weight | 451.615 g/mol |
|---|---|
| Formula | C26H37N5O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 8 |
cabergoline (81409-90-7)
Score:
#69 in Neurology
,
#349 in Neuroscience
,
#1593 in Biology
,
#1870 in Chemistry
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- A Comparison of Cabergoline and Bromocriptine in the Treatment of Hyperprolactinemic Amenorrhea (The New England Journal of Medicine, 1994)
- Cabergoline in the treatment of hyperprolactinemia : a study in 455 patients. (The Journal of Clinical Endocrinology and Metabolism, 1999)
- Cabergoline in the treatment of acromegaly : a study in 64 patients. (The Journal of Clinical Endocrinology and Metabolism, 1998)
- A mechanistic account of striatal dopamine function in human cognition: psychopharmacological studies with cabergoline and haloperidol. (Behavioral Neuroscience, 2006)
- Early Treatment of Parkinsons Disease with Cabergoline Delays the Onset of Motor Complications (Drugs, 1998)
- The Medical Treatment of Cushings Disease: Effectiveness of Chronic Treatment with the Dopamine Agonist Cabergoline in Patients Unsuccessfully Treated by Surgery (The Journal of Clinical Endocrinology and Metabolism, 2009)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
-
InChIKeyKORNTPPJEAJQIU-UHFFFAOYSA-N
- Pubchem - cabergoline
- Wikipedia - cabergoline
Cabergoline (brand names Dostinex and others), an ergot derivative, is a potent dopamine receptor agonist on D2 receptors. Rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph (prolactin) cells. It is frequently used as a first-line agent in the management of prolactinomas due to its higher affinity for D2 receptor sites, less severe side effects, and more convenient dosing schedule than the older bromocriptine.
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