| Weight | 323.132 g/mol |
|---|---|
| Formula | C11H12Cl2N2O5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
chloramphenicol (56-75-7, 2787-09-9)
Chloromycetin · Ophthochlor · Cloranfenicol
Score:
#102 in Biochemistry
,
#444 in Biology
,
#462 in Chemistry
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- Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. (Molecular and Cellular Biology, 1982)
- Nature of Col E1 Plasmid Replication in Escherichia coli in the Presence of Chloramphenicol (Journal of Bacteriology, 1972)
- A simple phase-extraction assay for chloramphenicol acyltransferase activity. (Gene, 1988)
- [57] Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria (Methods in Enzymology, 1975)
- High-copy-number and low-copy-number plasmid vectors for lacZ-complementation and chloramphenicol- or kanamycin-resistance selection (Gene, 1987)
- High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment (Nucleic Acids Research, 1984)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H303: May be harmful if swallowed
Warning Acute toxicity, oral - Category 5 - H350: May cause cancer
Danger Carcinogenicity - Category 1A, 1B - H372: Causes damage to organs through prolonged or repeated exposure
Danger Specific target organ toxicity, repeated exposure - Category 1 - Chloromycetin
- Ophthochlor
- Cloranfenicol
- Levomycetin
- Detreomycin
- Syntomycin
- Kloramfenikol
- Chlorocid
- Chlornitromycin
-
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-
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- Pubchem - chloramphenicol
- Wikipedia - chloramphenicol
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever.
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Synthesis
Reactant
+
4-Chloronitrobenzene
(Grignard alcohol)
NITROBENZENE
+
Reactant
(Friedel-Crafts alkylation)
2,2-Dichloroacetamide
+
Reactant
(Alkylation of primary amines)
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chloramphenicol
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