| Weight | 498.586 g/mol |
|---|---|
| Formula | C32H26N4O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 4 |
Conivaptan (210101-16-9)
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- Acute Hemodynamic Effects of Conivaptan, a Dual V1A and V2 Vasopressin Receptor Antagonist, in Patients With Advanced Heart Failure (Circulation, 2001)
- Assessment of the efficacy and safety of intravenous conivaptan in euvolemic and hypervolemic hyponatremia. (American Journal of Nephrology, 2007)
- Efficacy and Safety of Oral Conivaptan: A V1A/V2 Vasopressin Receptor Antagonist, Assessed in a Randomized, Placebo-Controlled Trial in Patients with Euvolemic or Hypervolemic Hyponatremia (The Journal of Clinical Endocrinology and Metabolism, 2006)
- Long-term treatment of patients with inappropriate secretion of antidiuretic hormone by the vasopressin receptor antagonist conivaptan, urea, or furosemide. (The American Journal of Medicine, 2001)
- Efficacy and Safety of the Vasopressin V1A/V2-Receptor Antagonist Conivaptan in Acute Decompensated Heart Failure: A Dose-Ranging Pilot Study (Journal of Cardiac Failure, 2008)
- Cardiovascular and renal effects of conivaptan hydrochloride (YM087), a vasopressin V1A and V2 receptor antagonist, in dogs with pacing-induced congestive heart failure. (European Journal of Pharmacology, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
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- Pubchem - Conivaptan
- Wikipedia - conivaptan
Conivaptan (YM 087, brand name Vaprisol) is a non-peptide inhibitor of arginine vasopressin (AVP)receptor. It was approved in 2004 for hyponatremia (low blood sodium levels). The compound was discovered by Astellas and marked in 2006.
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