| Weight | 218.216 g/mol |
|---|---|
| Formula | C10H10N4O2 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 1 |
DMPX (14114-46-6)
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- Scalable synthesis of substituted 2,7-dimethyl-9-phenylxanthen-9-ol (DMPx-OH): useful for the preparation of crystalline 5-O-DMPx-protected nucleosides (Tetrahedron Letters, 2012)
- A2 receptor-mediated modulation of the aortic baroreceptor and cardiopulmonary receptor reflexes in rabbits is antagonized by 3, 7-dimethyl-1-propargylxanthine (DMPX) (1999)
- P75 structure-activity relationships of DMPX (3,7-dimethyl-1-propargylxanthine) derivatives and analogs-potent A2-selective adenosine receptor antagonists (European Journal of Pharmaceutical Sciences, 1994)
- The influence of DMPX on the activity of common antidepressants (Acta Neurobiologiae Experimentalis, 2015)
- Influence of selective A2 adenosine receptor antagonist, DMPX, on the anticonvulsant activity of conventional antiepileptic drugs (Pharmacological Reports, 2013)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCN1C=NC2=C1C(=O)N(C(=O)N2C)CC#C
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InChIKeyIORPOFJLSIHJOG-UHFFFAOYSA-N
- Pubchem - DMPX
- Wikipedia - 3,7-dimethyl-1-propargylxanthine
DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A2 adenosine receptors, in contrast to the A1 subtype receptors. DMPX had 28 and 15 higher potency than caffeine in blocking peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED50 10 mol/kg) was similarly higher than caffeine.
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