| Weight | 429.904 g/mol |
|---|---|
| Formula | C22H24ClN3O4 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 10 |
Erlotinib hydrochloride (183319-69-9)
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- TRIBUTE: A Phase III Trial of Erlotinib Hydrochloride (OSI-774) Combined With Carboplatin and Paclitaxel Chemotherapy in Advanced NonSmall-Cell Lung Cancer (Journal of Clinical Oncology, 2005)
- Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1//Mdr1a/1b/ (triple-knockout) and wild-type mice (Molecular Cancer Therapeutics, 2008)
- Fresh from the Pipeline: Erlotinib hydrochloride (Nature Reviews Drug Discovery, 2005)
- Enhanced Sensitivity to the HER1/Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib Hydrochloride in Chemotherapy-Resistant Tumor Cell Lines (Clinical Cancer Research, 2005)
- A phase II, multicenter, randomized clinical trial to evaluate the efficacy and safety of bevacizumab in combination with either chemotherapy (docetaxel or pemetrexed) or erlotinib hydrochloride compared with chemotherapy alone for treatment of recurrent or refractory non-small cell lung cancer (Journal of Clinical Oncology, 2006)
- Design, optimization and in vitro evaluation of reverse micelle-loaded lipid nanocarriers containing erlotinib hydrochloride. (International Journal of Pharmaceutics, 2012)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
-
InChIKeyGTTBEUCJPZQMDZ-UHFFFAOYSA-N
- Pubchem - Erlotinib hydrochloride
- Wikipedia - erlotinib hydrochloride
Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the United States by Genentech and OSI Pharmaceuticals and elsewhere by Roche.
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Erlotinib hydrochloride
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