| Weight | 291.376 g/mol |
|---|---|
| Formula | C14H17N3O2S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
Fasudil (103745-39-7)
AT 877 · HA-1077 · 1-(5-isoquinolinesulfonyl)homopiperazine
Score:
#188 in Neurology
,
#845 in Neuroscience
,
#3703 in Biology
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- Suppression of Coronary Artery Spasm by the Rho-Kinase Inhibitor Fasudil in Patients With Vasospastic Angina (Circulation, 2002)
- Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension (Heart, 2005)
- Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina : a multicenter study (Journal of Cardiovascular Pharmacology, 2002)
- Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. (Journal of the American College of Cardiology, 2003)
- Effects of fasudil in acute ischemic stroke: Results of a prospective placebo-controlled double-blind trial (Journal of the Neurological Sciences, 2005)
- Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial (Journal of the American College of Cardiology, 2005)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - AT 877
- HA-1077
- 1-(5-isoquinolinesulfonyl)homopiperazine
- AT877
- AT-877
- HA 1077
- fasudil mesylate
- fasudil hydrochloride
-
SMILESC1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
-
InChIKeyNGOGFTYYXHNFQH-UHFFFAOYSA-N
- Pubchem - Fasudil
- Wikipedia - fasudil
Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension.
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Fasudil
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