| Weight | 238.243 g/mol |
|---|---|
| Formula | C11H14N2O4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
felbamate (25451-15-4)
Felbatol · Taloxa · Felbamyl
Score:
#46 in Neurology
,
#244 in Neuroscience
,
#1133 in Biology
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- P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the bloodbrain barrier: evidence from microdialysis experiments in rats (Neuroscience Letters, 2002)
- Felbamate monotherapy: Controlled trial in patients with partial onset seizures (Annals of Neurology, 1992)
- Mechanism of action of the anticonvulsant felbamate: Opposing effects on N-methyl-D-aspartate and -aminobutyric acidA receptors (Annals of Neurology, 1994)
- Comparative Anticonvulsant Activity and Neurotoxicity of Felbamate and Four Prototype Antiepileptic Drugs in Mice and Rats (Epilepsia, 1986)
- Felbamate monotherapy for partial-onset seizures: An active-control trial (Neurology, 1993)
- Felbamate for partial seizures Results of a controlled clinical trial (Neurology, 1991)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Felbatol
- Taloxa
- Felbamyl
- Wallace brand 2 of felbamate
- W-554
- 2-phenyl-1,3-propanediol dicarbamate
- ADD-03055
- Wallace brand 1 of felbamate
-
SMILESC1=CC=C(C=C1)C(COC(=O)N)COC(=O)N
-
InChIKeyWKGXYQFOCVYPAC-UHFFFAOYSA-N
- Pubchem - felbamate
- Wikipedia - felbamate
Felbamate (marketed under the brand name Felbatol by MedPointe) is an anticonvulsant used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with LennoxGastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drug's usage to severe refractory epilepsy.
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Synthesis
CARBAMIC ACID
+
Reactant
(Ester from carboxilic acid(SN2))
benzene
+
Reactant
(Friedel-Crafts alkylation)
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felbamate
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