| Weight | 358.218 g/mol |
|---|---|
| Formula | C12H14Cl2FNO4S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
Florfenicol (73231-34-2)
Score:
#4056 in Biology
,
#5111 in Chemistry
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- Sigma-Aldrich - Florfenicol144.50 USD
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- Molecular basis of bacterial resistance to chloramphenicol and florfenicol (Fems Microbiology Reviews, 2004)
- A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503 (Molecular Microbiology, 2005)
- Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates. (Antimicrobial Agents and Chemotherapy, 2006)
- Identification of a Plasmid-Borne Chloramphenicol-Florfenicol Resistance Gene in Staphylococcus sciuri (Antimicrobial Agents and Chemotherapy, 2000)
- Characterization of Chloramphenicol and Florfenicol Resistance in Escherichia coli Associated with Bovine Diarrhea (Journal of Clinical Microbiology, 2000)
- Detection of Multidrug-Resistant Salmonella enterica Serotype typhimurium DT104 Based on a Gene Which Confers Cross-Resistance to Florfenicol and Chloramphenicol (Journal of Clinical Microbiology, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCS(=O)(=O)C1=CC=C(C=C1)C(C(CF)NC(=O)C(Cl)Cl)O
-
InChIKeyAYIRNRDRBQJXIF-UHFFFAOYSA-N
- Pubchem - Florfenicol
- Wikipedia - florfenicol
Florfenicol (marketed by Schering-Plough Animal Health under the trade name Nuflor) is a fluorinated synthetic analog of thiamphenicol, mainly used in veterinary medicine. As a generic, it is now available worldwide.
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Synthesis
Reactant
+
4-Chlorophenyl methyl sulfone
(Grignard alcohol)
METHYL PHENYL SULFONE
+
Reactant
(Friedel-Crafts alkylation)
2,2-Dichloroacetamide
+
Reactant
(Alkylation of primary amines)
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Florfenicol
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