| Weight | 302.414 g/mol |
|---|---|
| Formula | C19H26O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 0 |
formestane (566-48-3)
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- Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer. (Annals of Oncology, 1994)
- Formestane versus megestrol acetate in postmenopausal breast cancer patients after failure of tamoxifen: a phase III prospective randomised cross over trial of second-line hormonal treatment (SAKK 20/90) (European Journal of Cancer, 1997)
- Anastrozole shows evidence of activity in postmenopausal patients who have responded or stabilised on formestane therapy (European Journal of Cancer, 1999)
- Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated breast cancer patients: Clinical and endocrine effects (European Journal of Cancer, 1996)
- Vorozole results in greater oestrogen suppression than formestane in postmenopausal women and when added to goserelin in premenopausal women with advanced breast cancer (Breast Cancer Research and Treatment, 1999)
- Pharmacological profiles of exemestane and formestane, steroidal aromatase inhibitors used for treatment of postmenopausal breast cancer (Breast Cancer Research and Treatment, 1998)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCC12CCC(=O)C(=C1CCC3C2CCC4(C3CCC4=O)C)O
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InChIKeyOSVMTWJCGUFAOD-UHFFFAOYSA-N
- Pubchem - formestane
- Wikipedia - formestane
Formestane, sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced.
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