| Weight | 445.545 g/mol |
|---|---|
| Formula | C21H27N5O4S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 7 |
glipizide (29094-61-9)
Glucotrol · Minidiab · K-4024
Score:
#887 in Biochemistry
,
#1029 in Physics
,
#2365 in Biology
,
#2931 in Chemistry
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- Sigma-Aldrich - glipizide80.10 - 271.95 USD
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- Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial (Diabetes, Obesity and Metabolism, 2007)
- Dapagliflozin Versus Glipizide as Add-on Therapy in Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control With Metformin A randomized, 52-week, double-blind, active-controlled noninferiority trial (Diabetes Care, 2011)
- Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells (Naunyn-schmiedebergs Archives of Pharmacology, 1988)
- Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2year study (International Journal of Clinical Practice, 2010)
- Saxagliptin is noninferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52week randomised controlled trial (International Journal of Clinical Practice, 2010)
- Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele. (Pharmacogenetics, 1999)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Glucotrol
- Minidiab
- K-4024
- Glidiazinamide
- Glupitel
- Glypidizine
- Minodiab
- K4024
- Mindiab
- Glydiazinamide
- K 4024
- Ozidia
- Melizide
-
SMILESCC1=NC=C(N=C1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
-
InChIKeyZJJXGWJIGJFDTL-UHFFFAOYSA-N
- Pubchem - glipizide
- Wikipedia - glipizide
Glipizide is an oral rapid- and short-acting anti-diabetic medication from the sulfonylurea class. It is classified as a second-generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation sulfonylureas are both more potent and have shorter half-lives than the first-generation sulfonylureas.
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Synthesis
AC1NCM73
+
Reactant
(Friedel-Crafts alkylation)
5-methylpyrazine-2-carbonyl chloride
+
Reactant
(Schotten-Baumann amide from acid)
Reactant
+
Cyclohexylurea
(Sulfonamide)
Reactant
+
CYCLOHEXYLAMINE
(Thiourea)
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glipizide
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