| Weight | 545.629 g/mol |
|---|---|
| Formula | C29H39NO9 |
| Hydrogen Acceptors | 10 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 9 |
homoharringtonine (26833-87-4)
Ceflatonin · omacetaxine mepesuccinate · homoharringtonine, 3H-labeled, (3(R))-isomer
Score:
#1515 in Biochemistry
,
#4429 in Chemistry
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- Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase (Blood, 1995)
- Homoharringtonine: History, current research, and future directions (Cancer, 2001)
- Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy. (Cancer, 2007)
- Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells (Molecular Cancer Therapeutics, 2006)
- Structures of harringtonine, isoharringtonine, and homoharringtonine (Tetrahedron Letters, 1970)
- Sequential homoharringtonine and interferon- in the treatment of early chronic phase chronic myelogenous leukemia (Blood, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Ceflatonin
- omacetaxine mepesuccinate
- homoharringtonine, 3H-labeled, (3(R))-isomer
-
SMILESCC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
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InChIKeyHYFHYPWGAURHIV-UHFFFAOYSA-N
- Pubchem - homoharringtonine
- Wikipedia - Homoharringtonine
Omacetaxine mepesuccinate (INN, trade names Synribo or Myelostat ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated for treatment of chronic myeloid leukemia (CML). It is a natural product first discovered in Cephalotaxus harringtonii, now manufactured by hemi-synthesis. It was approved by the US FDA in October 2012 for the treatment of adult patients with CML with resistance and/or intolerance to two or more tyrosine kinase inhibitors (TKIs).
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