| Weight | 354.41 g/mol |
|---|---|
| Formula | C19H22N4O3 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
Iclaprim (192314-93-5)
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- Iclaprim, a Novel Diaminopyrimidine with Potent Activity on Trimethoprim Sensitive and Resistant Bacteria. (Bioorganic & Medicinal Chemistry Letters, 2003)
- Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity (Journal of Antimicrobial Chemotherapy, 2009)
- In vitro activity of the novel diaminopyrimidine, iclaprim, in combination with folate inhibitors and other antimicrobials with different mechanisms of action (Journal of Antimicrobial Chemotherapy, 2007)
- Enantioselective Synthesis of Iclaprim EnantiomersA Versatile Approach to 2-Substituted Chiral Chromenes (Journal of Organic Chemistry, 2010)
- Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men (Journal of Antimicrobial Chemotherapy, 2007)
- Iclaprim, a diaminopyrimidine dihydrofolate reductase inhibitor for the potential treatment of antibiotic-resistant staphylococcal infections. (Current opinion in investigational drugs, 2008)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCOC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC
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- Pubchem - Iclaprim
- Wikipedia - iclaprim
Iclaprim is an antibiotic drug candidate that is active against Gram positive organisms. It is administered intravenously. In vitro, iclaprim is active against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), strains of Streptococcus pneumoniae resistant to several common antibiotics, and some Gram-negative bacteria.
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