| Weight | 531.44 g/mol |
|---|---|
| Formula | C26H28Cl2N4O4 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 7 |
ketoconazole (65277-42-1)
Nizoral · R41,400 · Ketoconazole Janssen Brand
Score:
#5 in Microbiology
,
#22 in Biochemistry
,
#151 in Biology
,
#155 in Chemistry
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- Terfenadine-ketoconazole interaction : pharmacokinetic and electrocardiographic consequences (JAMA, 1993)
- Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat (Toxicology and Industrial Health, 1999)
- Antiandrogen Withdrawal Alone or in Combination With Ketoconazole in Androgen-Independent Prostate Cancer Patients: A Phase III Trial (CALGB 9583) (Journal of Clinical Oncology, 2004)
- Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole (Clinical Pharmacology & Therapeutics, 1994)
- Ketoconazole Blocks Adrenal Steroid Synthesis (Annals of Internal Medicine, 1982)
- Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. (Journal of Clinical Investigation, 1983)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H301: Toxic if swallowed
Danger Acute toxicity, oral - Category 3 - H373: Causes damage to organs through prolonged or repeated exposure
Warning Specific target organ toxicity, repeated exposure - Category 2 - H410: Very toxic to aquatic life with long lasting effects
Warning Hazardous to the aquatic environment, long-term hazard - Category 1 - Nizoral
- R41,400
- Ketoconazole Janssen Brand
- R 41400
- Janssen Brand of Ketoconazole
- R-41400
- R41400
-
SMILESCC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
-
InChIKeyXMAYWYJOQHXEEK-UHFFFAOYSA-N
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