| Weight | 208.217 g/mol |
|---|---|
| Formula | C10H12N2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 4 |
L-kynurenine
2922-83-0, 343-65-7, 16055-80-4
Score:
#638 in Neuroscience
,
#1118 in Biochemistry
,
#2854 in Biology
,
#3573 in Chemistry
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- Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine. (Journal of Neurochemistry, 1989)
- l-Kynurenine Its synthesis and possible regulatory function in brain (Neurochemical Research, 1980)
- The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function (Blood, 2006)
- SYNTHESIS AND METABOLISM OF l-KYNURENINE IN RAT BRAIN (Journal of Neurochemistry, 1978)
- Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats (Journal of Cerebral Blood Flow and Metabolism, 1992)
- A Small-Molecule Screen Identifies l-Kynurenine as a Competitive Inhibitor of TAA1/TAR Activity in Ethylene-Directed Auxin Biosynthesis and Root Growth in Arabidopsis (The Plant Cell, 2011)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N
-
InChIKeyYGPSJZOEDVAXAB-UHFFFAOYSA-N
- Pubchem - L-kynurenine
- Wikipedia - L-kynurenine
L-Kynurenine () is a metabolite of the amino acid L-tryptophan used in the production of niacin. Kynurenine is synthesized by the enzyme tryptophan dioxygenase, which is made primarily but not exclusively in the liver, and indoleamine 2,3-dioxygenase, which is made in many tissues in response to immune activation. Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response.
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