| Weight | 581.069 g/mol |
|---|---|
| Formula | C29H26ClFN4O4S |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 11 |
Lapatinib
231277-92-2, 388082-78-8, 913989-15-8
Score:
#187 in Biochemistry
,
#764 in Biology
,
#835 in Chemistry
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- Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer (The New England Journal of Medicine, 2006)
- A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. (Cancer Research, 2004)
- Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial (The Lancet, 2012)
- Lapatinib Combined With Letrozole Versus Letrozole and Placebo As First-Line Therapy for Postmenopausal Hormone Receptor-Positive Metastatic Breast Cancer (Journal of Clinical Oncology, 2009)
- Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells (Cancer Research, 2006)
- Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer (Journal of Clinical Oncology, 2010)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
-
InChIKeyBCFGMOOMADDAQU-UHFFFAOYSA-N
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