| Weight | 495.639 g/mol |
|---|---|
| Formula | C29H38FN3O3 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 11 |
Mibefradil (116644-53-2)
Score:
#432 in Neuroscience
,
#713 in Biochemistry
,
#852 in Physics
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#1986 in Biology
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- Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967). (Molecular Pharmacology, 1995)
- Mibefradil Block of Cloned T-Type Calcium Channels (Journal of Pharmacology and Experimental Therapeutics, 2000)
- The T-Type Ca2+ Channel Blocker Mibefradil Prevents the Development of a Substrate for Atrial Fibrillation by Tachycardia-Induced Atrial Remodeling in Dogs (Circulation, 1999)
- Mibefradil Inhibition of T-Type Calcium Channels in Cerebellar Purkinje Neurons (Molecular Pharmacology, 1998)
- Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker (Journal of Hypertension, 1997)
- Life-Threatening Interaction of Mibefradil and -Blockers With Dihydropyridine Calcium Channel Blockers (JAMA, 1998)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)COC)C=C(C=C2)F
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InChIKeyHBNPJJILLOYFJU-UHFFFAOYSA-N
- Pubchem - Mibefradil
- Wikipedia - mibefradil
Mibefradil (Posicor) is a drug for the treatment of hypertension and chronic angina pectoris. It belongs to a group known as calcium channel blockers. The mechanism of action of mibefradil is characterized by the selective blockade of transient, low-voltage-activated (T-type) calcium channels over long-lasting, high-voltage-activated (L-type) calcium channels, which is probably responsible for many of its unique properties.
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