| Weight | 405.441 g/mol |
|---|---|
| Formula | C22H25F2NO4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 6 |
Nebivolol
118457-14-0, 118457-16-2, 99200-09-6, 118457-15-1
Score:
#610 in Neuroscience
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#1054 in Biochemistry
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#2735 in Biology
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#3430 in Chemistry
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- Sigma-Aldrich - Search for Nebivolol
- Fisher Scientific - Search for Nebivolol
- TCI - Search for Nebivolol
- Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS) (European Heart Journal, 2005)
- Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. (Journal of Pharmacology and Experimental Therapeutics, 1995)
- Nebivolol Reverses Endothelial Dysfunction in Essential Hypertension A Randomized, Double-Blind, Crossover Study (Circulation, 2001)
- Beta blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure) (Journal of the American College of Cardiology, 2009)
- Nebivolol: A Third-Generation beta-Blocker That Augments Vascular Nitric Oxide Release : Endothelial beta(2)-Adrenergic Receptor-Mediated Nitric Oxide Production. (Circulation, 2000)
- Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol. (Circulation, 2005)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
-
InChIKeyKOHIRBRYDXPAMZ-UHFFFAOYSA-N
- Pubchem - Nebivolol
- Wikipedia - nebivolol
Nebivolol is a 1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and, in Europe, also for left ventricular failure. It is highly cardioselective under certain circumstances.
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