| Weight | 529.526 g/mol |
|---|---|
| Formula | C28H22F3N7O |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 6 |
Nilotinib (641571-10-0)
Score:
#189 in Biochemistry
,
#772 in Biology
,
#846 in Chemistry
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- Nilotinib in Imatinib-Resistant CML and Philadelphia Chromosome-Positive ALL (The New England Journal of Medicine, 2006)
- Nilotinib versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia (The New England Journal of Medicine, 2010)
- Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance (Blood, 2007)
- Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets (Blood, 2007)
- OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. (Blood, 2006)
- Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)based mutagenesis screen: high efficacy of drug combinations (Blood, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
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- Pubchem - Nilotinib
- Wikipedia - nilotinib
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 1030 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.
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