Weight | 272.696 g/mol |
---|---|
Formula | C9H13ClN6O2 |
Hydrogen Acceptors | 6 |
Hydrogen Donors | 2 |
Aromatic Rings | 1 |
Rotatable Bonds | 5 |
NIMUSTINE (42471-28-3)
ACNU · NSC 245382
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- Effects of ACNU and radiotherapy on malignant glioma (Journal of Neurosurgery, 1986)
- Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma. (Journal of Clinical Oncology, 2003)
- Long-term follow-up results of 175 patients with malignant glioma : importance of radical tumour resection and postoperative adjuvant therapy with interferon : ACNU and radiation (Acta Neurochirurgica, 1994)
- Intra-arterial ACNU therapy for malignant brain tumors: Experimental studies and preliminary clinical results (Journal of Neurosurgery, 1983)
- Relationship between expression of O6-methylguanine-DNA methyltransferase, glutathione-S-transferase in glioblastoma and the survival of the patients treated with nimustine hydrochloride: An immunohistochemical analysis (Neurological Research, 2003)
- Phase II study of nimustine, carboplatin, vincristine, and interferon- with radiotherapy for glioblastoma multiforme: Experience of the Kyoto Neuro-Oncology Group (Journal of Neurosurgery, 2006)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - ACNU
- NSC 245382
-
SMILESCC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O
-
InChIKeyVFEDRRNHLBGPNN-UHFFFAOYSA-N
- Pubchem - NIMUSTINE
- Wikipedia - nimustine
Nimustine (INN) is a nitrosourea alkylating agent.
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Synthesis
1-(2-Chloroethyl)-1-nitrosourea
+
5-(Chloromethyl)-2-methylpyrimidin-4-amine
(Alkylation of primary amines)
Reactant
+
5-(AMINOMETHYL)-2-METHYLPYRIMIDIN-4-AMINE
(Schotten-Baumann amide from acid)
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