| Weight | 274.272 g/mol |
|---|---|
| Formula | C15H14O5 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
phloretin (60-82-2)
Score:
#1312 in Biochemistry
,
#3209 in Biology
,
#4015 in Chemistry
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- A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture. (Analytical Biochemistry, 1975)
- Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport (Journal of Pharmacology and Experimental Therapeutics, 2002)
- Effect of phloretin on the permeability of thin lipid membranes. (The Journal of General Physiology, 1976)
- Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct (Proceedings of the National Academy of Sciences of the United States of America, 2004)
- The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids (Biochemical and Biophysical Research Communications, 2002)
- The Attachment of Phloretin and Analogues to Human Erythrocytes in Connection with Inhibition of Sugar Transport (Journal of Biological Chemistry, 1959)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
-
InChIKeyVGEREEWJJVICBM-UHFFFAOYSA-N
- Pubchem - phloretin
- Wikipedia - phloretin
Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot.
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Synthesis
phloroglucinol
+
Reactant
(Friedel-Crafts acylation)
Phenol
+
Reactant
(Friedel-Crafts alkylation)
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phloretin
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