| Weight | 275.352 g/mol |
|---|---|
| Formula | C15H21N3O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
physostigmine (57-47-6)
Eserine
Score:
#345 in Neuroscience
,
#1576 in Biology
,
#1849 in Chemistry
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- THE INHIBITION OF CHOLINESTERASE BY PHYSOSTIGMINE AND PROSTIGMINE (Journal of Biological Chemistry, 1942)
- Neocortical and hippocampal activation relation to behavior: effects of atropine, eserine, phenothiazines, and amphetamine. (Journal of Comparative and Physiological Psychology, 1975)
- Physostigmine: Improvement of Long-Term Memory Processes in Normal Humans. (Science, 1978)
- Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia. (British Journal of Psychiatry, 1981)
- Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine (Neuroscience, 1985)
- Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task (Experimental Brain Research, 1992)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H300: Fatal if swallowed
Danger Acute toxicity, oral - Category 1, 2 - H373: Causes damage to organs through prolonged or repeated exposure
Warning Specific target organ toxicity, repeated exposure - Category 2 - Eserine
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SMILESCC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
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InChIKeyPIJVFDBKTWXHHD-UHFFFAOYSA-N
- Pubchem - physostigmine
- Wikipedia - physostigmine
Physostigmine (also known as eserine from sr, the West African name for the Calabar bean) is a highly toxic parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor. It occurs naturally in the Calabar bean and the Manchineel tree. The chemical was synthesized for the first time in 1935 by Percy Lavon Julian and Josef Pikl.
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